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Lal S, Randall WC, Taylor AH, Kappler F, Walker M, Brown TR, Szwergold BS
Fructose-3-phosphate production and polyol pathway metabolism in diabetic rat hearts
Metabolism-Clinical and Experimental (1997) 46:1333-1338.
Abstract
Previous studies have suggested that polyol-pathway and nonenzymatic glycation may be involved in the development of cardiac myopathy, a well-known manifestation of diabetes. Although the exact etiology of this complication is not fully understood, it is likely to be multifactorial. In this study, we investigated the metabolic consequences of diabetes and the effect of aldose reductase inhibitor (ARI) treatment on cardiac tissues of Sprague-Dawley rats. Perchloric acid (PCA) extracts of hearts from the animals were examined using P-31-nuclear magnetic resonance (NMR), gas chromatography/mass spectrometry IGC/MS), and high-performance liquid chromatography (HPLC). In P-31-NMR spectra of diabetic animals, a peak resonating at the chemical shift of 5.8 ppm with a coupling constant of 10 Hz was identified as fructose-3-phosphate (F3P). Undetectable in controls (
Note
Publication Date: 1997-11-01.
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