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Kappes DJ, Alarcon B, Regueiro JR
T-Lymphocyte Receptor Deficiencies
Current Opinion in Immunology (1995) 7:441-447.
Signalling through the TCR is mediated by the cytoplasmic tails of the CD3 complex. Deficiencies in the expression of different CD3 components have lead to dramatic, yet dissimilar, effects on T-cell development and to selective deficits in peripheral T-cell subsets. Recent studies of human patients and animal models with CD3 deficiencies are providing insights into the redundant and unique roles of these molecules.
Publication Date: 1995-08-01.
Last updated on Monday, May 04, 2020