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Johnson JE, Varkonyi RJ, Schwalm J, Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D
Multiple Mechanisms of Telomere Maintenance Exist in Liposarcomas
Clinical Cancer Research (2005) 11:5347-5355.
Abstract
PURPOSE: Telomeres are specialized nucleoprotein complexes that protect and confer stability upon chromosome ends. Loss of telomere function as a consequence of proliferation-assocd. sequence attrition results in genome instability, which may facilitate carcinogenesis by generating growth-promoting mutations. However, unlimited cellular proliferation requires the maintenance of telomeric DNA; thus, the majority of tumor cells maintain their telomeres either through the activity of telomerase or via a mechanism known as alternative lengthening of telomeres (ALT). Recent data suggest that constitutive telomere maintenance may not be required in all tumor types. Here we assess the role and requirement of telomere maintenance in liposarcoma. Exptl. Design: Tumor samples were analyzed with respect to telomerase activity, telomere length, and the presence of ALT-specific subcellular structures, ALT-assocd. promyelocytic leukemia nuclear bodies. This multiassay assessment improved the accuracy of categorization. RESULTS: Our data reveal a significant incidence (24%) of ALT-pos. liposarcomas, whereas telomerase is used at a similar frequency (27%). A large no. of tumors (49%) do not show characteristics of telomerase or ALT. In addn., telomere length was always shorter in recurrent disease, regardless of the telomere maintenance mechanism. CONCLUSIONS: These results suggest that approx. one half of liposarcomas either employ a novel constitutively active telomere maintenance mechanism or lack such a mechanism. Anal. of recurrent tumors suggests that liposarcomas can develop despite limiting or undetectable activity of a constitutively active telomere maintenance mechanism. [on SciFinder (R)]
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Publication Date: 2005-01-01.
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