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Jin Y, Xia MC, Saylor CM, Narayan K, Kang J, Wiest DL, Wang YM, Xiong N
Cutting Edge: Intrinsic Programming of Thymic gamma delta T Cells for Specific Peripheral Tissue Localization
Journal of Immunology (2010) 185:7156-7160.
Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial gamma delta T cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skin-homing potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR-ligand interaction. These studies reveal that development of the tissue-specific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions. The Journal of Immunology, 2010, 185: 7156-7160.
Publication Date: 2010-12-01.
PMCID: PMC3023158
Last updated on Wednesday, August 05, 2020