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Hayakawa K, Asano M, Shinton SA, Gui M, Allman D, Stewart CL, Silver J, Hardy RR
Positive selection of natural autoreactive B cells
Science (1999) 285:113-116.
Lymphocyte development is critically influenced by self- antigens. T cells are subject to both positive and negative selection, depending on their degree of seif-reactivity. Although B cells are subject to negative selection, it has been difficult to test whether self-antigen plays any positive role in B cell development. A murine model system of naturally generated autoreactive B cells with a germ Line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen promotes B cell accumulation and serum autoantibody secretion. Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity.
Publication Date: 1999-07-02.
Last updated on Tuesday, December 04, 2018