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Gonen O, Mohebbi A, Stoyanova R, Brown TR
In vivo phosphorus polarization transfer and decoupling from protons in three-dimensional localized nuclear magnetic resonance spectroscopy of human brain
Magnetic Resonance in Medicine (1997) 37:301-306.
Abstract
Refocused insensitive nucleus enhancement by polarization transfer (RINEPT) from protons (H-1) to a J-coupled phosphorus (P-31) has been incorporated into three-dimensional (3D) chemical-shift-imaging (CSI) sequence on a clinical imager. The technique is demonstrated on a phantom and in in vivo human brain. The polarization-transfer efficiency (similar to 1.2) is tower than the theoretical maximum of gamma(1H)/gamma(31P) approximate to 2.4 resulting from H-1-H-1 homonuclear J couplings of similar magnitude competing with the H-1 --> P-31 transfer. Nevertheless, compared with direct P-31 Ernst-angle excitation, signal gains of up to x1.8 were obtained mainly as a result of T-1 differences between P-31 and the H-1. Spectral interpretation is simplified by editing out all non-proton- coupled P-31 signals. The duration, similar to 50 min, and power deposition, similar to 1 W . kg(-1), make the application suitable for human studies.
Note
Publication Date: 1997-02-01.
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