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Gauvin TJ, Fukui J, Peterson JR, Higgs HN
Isoform-Selective Chemical Inhibition of mDia-Mediated Actin Assembly
Biochemistry (2009) 48:9327-9329.
Formins are potent actin assembly factors. Diaphanous formins, including mDial, mDia2, and mDia3 in mammals, are implicated in mitosis and cytokinesis, but no chemical interactors have been reported. We developed an in vitro screen for inhibitors of actin assembly by mDial and identified an inhibitor of mDial and mDia2 that does not inhibit mDia3 at the concentrations tested. These results establish the druggability of mDia formins and introduce a first-generation inhibitor.
MeSH terms
formins proteins
Publication Date: 2009-10-01.
PMCID: PMC2758331
Last updated on Wednesday, March 04, 2020