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Fang M, Orr MT, Spee P, Egebjerg T, Lanier LL, Sigal LJ
CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
Immunity (2011) 34:579-89.
Abstract
It is well established that natural killer (NK) cells confer resistance to many viral diseases, but in only a few instances the molecular mechanisms whereby NK cells recognize virus-infected cells are known. Here we show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus. Ectromelia virus-infected cells expressing the major histocompatibility complex (MHC) class Ib molecule Qa-1(b) are specifically recognized by the activating receptor formed by CD94 and NKG2E. Because CD94-NKG2 receptors and their ligands are highly conserved in rodents and humans, a similar mechanism may exist during human infections with the smallpox and monkeypox viruses, which are highly homologous to ectromelia virus.
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Publication Date: 2011-04-22.
PMCID: PMC3081423
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Last updated on Tuesday, December 04, 2018