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Daniel R, Katz RA, Skalka AM
A role for DNA-PK in retroviral DNA integration
Science (1999) 284:644-647.
Retroviral DNA integration is catalyzed by the viral protein integrase. Here, it is shown that DNA-dependent protein kinase (DNA-PK), a host cell protein, also participates in the reaction. DNA-PK-deficient murine scid cells infected with three different retroviruses showed a substantial reduction in retroviral DNA integration and died by apoptosis. Scid cell killing was not observed after infection with an integrase- defective virus. suggesting that abortive integration is the trigger for death in these DNA repair-deficient cells. These results suggest that the initial events in retroviral integration are detected as DNA damage by the host cell and that completion of;the integration process requires the DNA-PK- mediated repair pathway.
Publication Date: 1999-04-23.
Last updated on Saturday, August 22, 2020