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Cai KQ, Klein-Szanto A, Karthik D, Edelson M, Daly MB, Ozols RF, Lynch HT, Godwin AK, Xu XX
Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations
Gynecologic Oncology (2006) 103:719-728.
Abstract
MeSH terms
BRCA1 MICE BRCA2 CARRIERS menopause TUMORIGENESIS WOMEN ovarian SURFACE FAMILY-HISTORY aging prophylactic oophorectomies ovulation pre-malignant lesion etiological factor PROPHYLACTIC OOPHORECTOMY SPECIMENS CANCER-RISK OVULATION GONADOTROPINS AB Objective From analysis of pre-cancer ovarian tissues obtained from several studies reported the increased prophylactic oophorectomies but whether these ovarian morphological changes in high-risk ovaries morphological changes are associated with BRCA BRCA2 genotypes or are we have investigated a recent cancer precursors is controversial Here collection of ovaries from prophylactic oophorectomies and control ovaries from surgeries due to other non-ovarian-related cancer or non-neoplastic diseases to determine if ovarian morphological changes Methods We assembled a panel of archived ovarian tissues: 52 ovarian tissue blocks were from prophylactic oophorectomies of a high-risk (HR) 66 ovaries were from surgeries due to non-ovarian-related referred to as normal-risk (NR) group The morphology of diseases and morphological changes including ovarian tissues was examined invaginations papillomatosis-inclusion cysts-and epithelial stratification were assessed in a blinded fashion Results No statistically significant difference in frequency of these inclusion cysts and deep invaginations were found much more commonly in women age 45-54 of either HR or NR groups Conclusions This study suggests that no significant increase in the presence of non-neoplastic ovarian morphological changes is associated population with BRCA1 the frequency of these histological BRCA2 mutations Rather especially inclusion cysts features-may associate with age or menopausal status We propose that ovulatory and perimenopausal and gonadotropin stimulation produces ovarian morphological changes these histological features may promote the transformation of genetically compromised epithelial cells in the development of ovarian cancer relate to BRCA1 epithelium 2 genotypes or reproductive history cancer (c) 2006 Elsevier Inc All rights reserved histolopathologic features was found between HR and NR groups However
Note
Publication Date: 2006-11-01.
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