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Bain G, Maandag EC, Riele H, Feeney AJ, Sheehy A, Schlissel M, Shinton SA, Hardy RR, Murre C
Both E12 and E47 allow commitment to the B cell lineage
Immunity (1997) 6:145-154.
The E2A gene products, E12 and E47, are required for proper B cell development. Mice lacking the E2A gene products generate only a very small number of 8220(+) cells, which lack immunoglobulin DJ(H) rearrangements. We have now generated mice expressing either E12 or E47. B cell development in mice expressing E12 but lacking E47 is perturbed at the pro-B cell stage, and these mice lack IgM(+)B220(+) B cells in both bone marrow and spleen. IgM(+)B220(+) B cells can be detected, albeit at significantly reduced levels, in the bone marrow and spleen of mice lacking E12. Ectopic expression of both E12 and E47 in a null mutant background shows that E12 and E47 act in concert to promote B lineage development. Taken together, the data indicate that both E12 and E47 allow commitment to the B cell lineage and act synergistically to promote B lymphocyte maturation.
Publication Date: 1997-02-01.
Last updated on Tuesday, December 04, 2018