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Maluchenko NV, Sultanov DS, Kotova EY, Kirpichnikov MP, Studitsky VM, Feofanov AV
Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes
Dokl Biochem Biophys (2019) 489:377-379.
PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.
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Publication Date: 2019-11-01.
Last updated on Saturday, August 22, 2020