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Zarrabi K, Masic S, Schaefer C, Bartel MJ, Kutikov A, Zibelman M
Neoadjuvant checkpoint inhibition in renal cell carcinoma associated Stauffer's syndrome
Urol Case Rep (2020) 29:101077.
Stauffer's syndrome is a paraneoplastic phenomenon associated with renal cell carcinoma (RCC) characterized by cholestatic hepatitis. We explore the effects of perioperative immunotherapy in a case of Stauffer's syndrome. A 70-year-old female with a locally advanced clear cell RCC (ccRCC) developed severe hyperbilirubinemia. The patient's cholestasis progressed despite initial systemic immunotherapy, but improved after cytoreductive nephrectomy. The patient continued immunotherapy post-operatively and regained normalized hepatic function. To our knowledge, this is the first case reporting use of systemic immunotherapy with surgery in Stauffer's syndrome, and we provide clinical insight into a treatment regimen which may be employed in future cases.
Publication Date: 2020-03-01.
PMCID: PMC6911965
Last updated on Thursday, April 02, 2020