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McIntosh AG, Parker DC, Egleston BL, Uzzo RG, Haseebuddin H, Joshi SS, Viterbo R, Greenberg RE, Chen DY, Smaldone MC, Kutikov A
Prediction of Significant Estimated Glomerular Filtration Rate Decline Following Renal Unit Removal to Aid in the Clinical Choice between Radical and Partial Nephrectomy in Patients with Renal Mass and Normal Renal Function
BJU Int (2019) 124:999-1005.
OBJECTIVES: To develop a clinically actionable predictive model to quantitate the risk of estimated glomerular filtration rate decline to 60 ml/min/1.73m(2) who underwent radical nephrectomy for a localized renal mass. New baseline renal function was indexed. We used multivariable logistic regression to develop a predictive nomogram and evaluated it utilizing receiver operating characteristic analysis. Decision curve analysis assessed the net clinical benefit. RESULTS: 668 patients met inclusion criteria. 183 patients (27%) experienced estimated glomerular filtration rate decline to ~11%. CONCLUSIONS: The decision to perform radical vs. partial nephrectomy is multifaceted. We provide a simple quantitative tool to help identify patients at risk of a post-operative eGFR of
Publication Date: 2019-05-30.
Last updated on Saturday, June 06, 2020