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Jonna S, Feldman RA, Swensen J, Gatalica Z, Korn WM, Borghaei H, Ma PC, Nieva JJ, Spira AI, VanderWalde AM, Wozniak AJ, Kim ES, Liu SV
Detection of NRG1 gene fusions in solid tumors
Clin Cancer Res (2019) 25:4966-4972.
BACKGROUND: NRG1 gene fusions are rare but potentially actionable oncogenic drivers present in some solid tumors. Details regarding the incidence of these gene rearrangements are lacking. Here, we assessed the incidence of NRG1 fusions across multiple tumor types and described fusion partners. METHODS: Tumor specimens submitted for molecular profiling at a CLIA-certified genomics laboratory and that underwent fusion testing by anchored multiplex PCR for targeted RNA sequencing were retrospectively identified. The overall and tumor-specific incidence was noted as was the specific fusion partner. RESULTS: Out of 21,858 tumor specimens profiled from September 2015 to December 2018, 41 cases (0.2%) harbored an NRG1 fusion. Multiple fusion partners were identified. Fusion events were seen across tumor types. The greatest incidence was in non-small cell lung cancer (25), though this represented only 0.3% of non-small cell lung cancer cases tested. Other tumor types harboring an NRG1 fusion included gallbladder cancer, renal cell carcinoma, bladder cancer, ovarian cancer, pancreatic cancer, breast cancer, neuroendocrine tumor, sarcoma, and colorectal cancer. CONCLUSION: NRG1 fusions can be detected at a low incidence across multiple tumor types with significant heterogeneity in fusion partner.
Publication Date: 2019-04-15.
Last updated on Saturday, August 22, 2020