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Parham LR, Williams PA, Chatterji P, Whelan KA, Hamilton KE
RNA regulons are essential in intestinal homeostasis
Am J Physiol Gastrointest Liver Physiol (2019) 316:G197-G204.
Intestinal epithelial cells are among the most rapidly proliferating cell types in the human body. There are several different sub-types of epithelial cells, each with unique functional roles in responding to the ever-changing environment. The epithelium's ability for rapid and customized responses to environmental changes requires multi-tiered levels of gene regulation. An emerging paradigm in gastrointestinal epithelial cells is the regulation of functionally-related mRNA families, or regulons, via RNA binding proteins (RBPs). RBPs represent a rapid and efficient mechanism to regulate gene expression and cell function. In this review, we will provide an overview of intestinal epithelial RBPs and how they contribute specifically to intestinal epithelial stem cell dynamics. In addition, we will highlight key gaps in knowledge in the global understanding of RBPs in gastrointestinal physiology as an opportunity for future studies.
Publication Date: 2019-01-01.
PMCID: PMC6383383
Last updated on Wednesday, February 05, 2020