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Upshaw JN, O'Neill A, Carver JR, Dimond EP, Denlinger CS, Kircher SM, Wagner LI, Ky B, Brell JM
Fluoropyrimidine Cardiotoxicity: Time for a Contemporaneous Appraisal
Clin Colorectal Cancer (2019) 18:44-51.
Abstract
INTRODUCTION: Fluoropyrimidines (FPDs) are a fundamental component of many chemotherapy regimens. Cardiotoxic adverse events (AEs) such as angina, ischemia, arrhythmias, and cardiomyopathy associated with 5-fluorouracil (5-FU) and capecitabine (CAPE) have been sparingly described in studies, primarily through case reports. Data from the 1990s revealed an estimated incidence of 0.5% to 19%, with cardiovascular fatalities occurring in
Note
Publication Date: 2019-03-01.
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Last updated on Friday, December 06, 2019