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Perez-Guijarro E, Day CP, Merlino G, Zaidi MR
Genetically engineered mouse models of melanoma
Cancer (2017) 123:2089-2103.
Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089-103. (c) 2017 American Cancer Society.
Publication Date: 2017-06-01.
PMCID: PMC5445933
Last updated on Thursday, July 16, 2020