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Chatare VK, Andrade RB
Total Synthesis of (-)-Albocycline
Angew Chem Int Ed Engl (2017) 56:5909-5911.
Abstract
The macrolactone natural product (-)-albocycline is a promising antibiotic candidate for the treatment of both methicillin resistant Staphylococcus aureus (MRSA) and vancomycin-resistant strains. Herein we report a concise total synthesis of (-)-albocycline in 14 steps from commercially available methyl (R)-3-hydroxybutyrate. Novel key steps include the highly regio- and stereoselective reactions of chiral N-sulfinyl metallodienamines (NSMDs) with aldehydes and the Davis oxaziridine, in addition to the Horner-Wadsworth-Emmons olefination of N-sulfinyl imines.
Note
Publication Date: 2017-05-15.
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Last updated on Thursday, November 02, 2017