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Fatkhullina AR, Peshkova IO, Koltsova EK
The role of cytokines in the development of atherosclerosis
Biochemistry-Moscow (2016) 81:1358-1370.
Atherosclerosis contributes to the development of many cardiovascular diseases, which remain the leading cause of death in developed countries. Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries. It is caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a key factor at all stages of atherosclerosis progression. Cells involved in pathogenesis of atherosclerosis were shown to be activated by soluble factors, cytokines, that strongly influence the disease development. Pro-inflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. In this review, we discuss the latest findings on the role of cytokines in the development and progression of atherosclerosis.
Publication Date: 2016-11-01.
PMCID: PMC5471837
Last updated on Tuesday, July 07, 2020