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Development of gammadelta T Cells, the Special-Force Soldiers of the Immune System
Methods Mol Biol (2016) 1323:23-32.
While the functions of alphabeta T cells in host resistance to pathogen infection are understood in far more detail than those of gammadelta lineage T cells, gammadelta T cells perform critical, essential functions during immune responses that cannot be compensated by alphabeta T cells. Accordingly, it is essential to understand how the development of gammadelta T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will cover the basic processes that underlie gammadelta T cell development in the thymus, as well as the current understanding of how they are controlled.
Publication Date: 2016-01-01.
Last updated on Wednesday, June 03, 2020