Lattice_grid_med
Powered by LatticeGrid

Search Enter term and hit return. Use '*' for as a wildcard.
Tarawneh A, Leon F, Pettaway S, Elokely KM, Klein ML, Lambert J, Mansoor A, Cutler SJ
Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors
J Nat Prod (2015) 78:1461-5.
Abstract
Bioassay-guided fractionation of the leaves of Perovskia atriplicifolia (Russian sage) resulted in the isolation of four previously known flavonoid derivatives, 5-hydroxy-6,7,3',4'-tetramethoxyflavone (1), 5,7-dihydroxy-6,3',4'-trimethoxyflavone (2), 5-hydroxy-6,7,4'-trimethoxyflavone (3), and 5,7-dihydroxy-6,4'-dimethoxyflavone (4). Compounds 1, 3, and 4 showed displacement of the radioligand for the cloned human delta opioid receptor with Ki values ranging from 3.1 to 26.0 muM. In addition, the binding mode of the compounds in the active site of the delta opioid receptor was investigated through molecular modeling algorithms. This study may have implications in better understanding non-nitrogenous delta opioid receptor ligands.
Note
Publication Date: 2015-06-26.
Back
Last updated on Wednesday, March 04, 2020