Powered by LatticeGrid

Search Enter term and hit return. Use '*' for as a wildcard.
Radu M, Semenova G, Kosoff R, Chernoff J
PAK signalling during the development and progression of cancer
Nat Rev Cancer (2013) 14:13-25.
p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic signalling pathways. Overexpression or mutational activation of PAK isoforms frequently occurs in various human tumours, and recent data suggest that excessive PAK activity drives many of the cellular processes that are the hallmarks of cancer. In this Review, we discuss the mechanisms of PAK activation in cancer, the key substrates that mediate the developmental and oncogenic effects of this family of kinases, and how small-molecule inhibitors of these enzymes might be best developed and deployed for the treatment of cancer.
MeSH terms
Publication Date: 2013-12-23.
Last updated on Tuesday, June 05, 2018