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Gordiev M, Engstrom PF, Khasanov R, Moroshek A, Sitdikov R, Dgavoronkov V, Schnoll RA
Genetic analysis of polymorphisms in dopamine receptor and transporter genes for association with smoking among cancer patients
European Addiction Research (2013) 19:105-111.
Abstract
Background: Smoking among Russian cancer patients may be related to variations in the DRD2/ANKK1 (Taq1), DRD4 (exon III VNTR), and SLC6A3 genes. Methods: Seven hundred fifty patients provided smoking history and DNA. Results: Current smokers were more likely to be DRD2 A2 allele carriers versus nonsmokers (former/never smokers; 69 vs. 56%; OR = 1.69; 95% CI 1.13-2.53, p = 0.01) and former smokers (69 vs. 59%; OR = 1.54; 95% CI 0.97-2.46, p = 0.07). Ever smokers (current/former smokers) were more likely to be DRD2 A2 allele carriers versus never smokers (65 vs. 55%; OR = 1.50; 95% CI 1.00-2.27, p = 0.05). The risk of current smoking among DRD2 A2 allele carriers was present if the DRD4 short allele was also present (OR = 1.76; 95% CI 1.12-2.78, p = 0.02), and the risk of ever smoking among DRD2 A2 allele carriers was present if the DRD4 short allele was also present (OR = 1.62; 95% CI 1.02-2.55, p = 0.04). DRD2 A2 allele carriers had a shorter period of previous abstinence versus DRD2 A1 carriers (p = 0.02). Effects were not statistically significant when controlling for multiple comparisons. Conclusions: The DRD2 A2 allele may increase the risk of smoking among cancer patients, convergent with studies using non-Western samples. However, additional replication is needed. (PsycINFO Database Record (c) 2013 APA, all rights reserved) (journal abstract).
Note
Publication Date: 2013-02-01.
PMCID: PMC 3649069
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