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Gorin A, Gabitova L, Astsaturov I
Regulation of cholesterol biosynthesis and cancer signaling
Current Opinion in Pharmacology (2012) 12:710-716.
Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.
Publication Date: 2012-12-01.
PMCID: PMC 3504641
Last updated on Saturday, August 22, 2020