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Fang M, Siciliano NA, Hersperger AR, Roscoe F, Hu A, Ma XY, Shamsedeen AR, Eisenlohr LC, Sigal LJ
Perforin-dependent CD4(+) T-cell cytotoxicity contributes to control a murine poxvirus infection
Proceedings of the National Academy of Sciences of the United States of America (2012) 109:9983-9988.
CD4(+) T cells are generally regarded as helpers and regulators of the immune response. Although cytolytic CD4(+) T cells have been described, whether those generated during the course of a viral infection play a role in virus control remains unknown. Here we show that during acute infection with ectromelia virus, the mouse homolog of the human virus of smallpox, large numbers of CD4(+) T cells in the draining lymph node and liver of resistant mice have a cytotoxic phenotype. We also show that these cells kill targets in vivo in a perforin-dependent manner and that mice with specific deficiency of perforin in CD4(+) T cells have impaired virus control. Thus, perforin-dependent CD4(+) T-cell killing of infected cells is an important mechanism of antiviral defense.
Publication Date: 2012-06-01.
PMCID: PMC3382508
Last updated on Wednesday, February 05, 2020