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Hyslop T, Weinberg DS, Schulz S, Barkun A, Waldman SA
Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer
Journal of Surgical Oncology (2012) 106:24-30.
Background and Objectives Recurrence in lymph node-negative (pN0) colorectal cancer suggests the presence of undetected occult metastases. Occult tumor burden in nodes estimated by GUCY2C RT-qPCR predicts risk of disease recurrence. This study explored the impact of the number of nodes analyzed by RT-qPCR (analytic) on the prognostic utility of occult tumor burden. Methods Lymph nodes (range: 2-159) from 282 prospectively enrolled pN0 colorectal cancer patients, followed for a median of 24 months (range: 263), were analyzed by GUCY2C RT-qPCR. Prognostic risk categorization defined using occult tumor burden was the primary outcome measure. Association of prognostic variables and risk category were defined by multivariable polytomous and semi-parametric polytomous logistic regression. Results Occult tumor burden stratified this pN0 cohort into categories of low (60%; recurrence rate (RR)?=?2.3% [95% CI 0.14.5%]), intermediate (31%; RR?=?33.3% [23.744.1%]), and high (9%; RR?=?68.0% [46.585.1%], P?12 nodes were analyzed, occult tumor burden almost completely resolved prognostic risk classification of pN0 patients. Conclusions The prognostic utility of occult tumor burden assessed by GUCY2C RT-qPCR is dependent on the number of analytic lymph nodes. J. Surg. Oncol. 2012; 106:2430. (C) 2012 Wiley Periodicals, Inc.
Publication Date: 2012-07-01.
PMCID: PMC3370134
Last updated on Wednesday, February 05, 2020