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Jones-Mason ME, Zhao XD, Kappes D, Lasorella A, Iavarone A, Zhuang Y
E Protein Transcription Factors Are Required for the Development of CD4(+) Lineage T Cells
Immunity (2012) 36:348-361.
The double-positive (DP) to single-positive (SP) transition during T cell development is initiated by downregulation of the E protein transcription factors HEB and E2A. Here, we have demonstrated that in addition to regulating the onset of this transition, HEB and E2A also play a separate role in CD4(+) lineage choice. Deletion of HEB and E2A in DP thymocytes specifically blocked the development of CD4(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 allowed CD4(+) T cell development but blocked CD8(+) lineage development. Analysis of the CD4(+) lineage transcriptional regulators ThPOK and Gata3 placed HEB and E2A upstream of CD4(+) lineage specification. These studies identify an important role for E proteins in the activation of CD4(+) lineage differentiation as thymocytes undergo the DP to SP transition.
Publication Date: 2012-03-01.
PMCID: PMC3431168 [Available on 2013/3/23]
Last updated on Friday, August 14, 2020