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Abrams RA, Winter KA, Regine WF, Safran H, Hoffman JP, Lustig R, Konski AA, Benson AB, Macdonald JS, Rich TA, Willett CG
FAILURE TO ADHERE TO PROTOCOL SPECIFIED RADIATION THERAPY GUIDELINES WAS ASSOCIATED WITH DECREASED SURVIVAL IN RTOG 9704-A PHASE III TRIAL OF ADJUVANT CHEMOTHERAPY AND CHEMORADIOTHERAPY FOR PATIENTS WITH RESECTED ADENOCARCINOMA OF THE PANCREAS
International Journal of Radiation Oncology Biology Physics (2012) 82:809-816.
Abstract
Purpose: In Radiation Therapy Oncology Group 9704, as previously published, patients with resected pancreatic adenocarcinoma received continuous infusion 5-FU and concurrent radiotherapy (5FU-RT). 5FU-RT treatment was preceded and followed by randomly assigned chemotherapy, either 5-FU or gemcitabine. This analysis explored whether failure to adhere to specified RT guidelines influenced survival and/or toxicity. Methods and Materials: RT requirements were protocol specified. Adherence was scored as per protocol (PP) or less than per protocol (
Note
Publication Date: 2012-02-01.
PMCID: PMC133855
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