Powered by LatticeGrid

Search Enter term and hit return. Use '*' for as a wildcard.
Yip SC, Saha S, Chernoff J
PTP1B: a double agent in metabolism and oncogenesis
Trends in Biochemical Sciences (2010) 35:442-449.
PTP1B, a non-transmembrane protein tyrosine phosphatase that has long been studied as a negative regulator of insulin and leptin signaling, has received renewed attention as an unexpected positive factor in tumorigenesis. Here, we highlight how views of this enzyme have evolved from regarding it as a simple metabolic off-switch to a more complex view of PTP1B as an enzyme that can play both negative and positive roles in diverse signaling pathways. These dual characteristics make PTP1B a particularly attractive therapeutic target for diabetes, obesity, and perhaps breast cancer.
Publication Date: 2010-08-01.
PMCID: PMC2917533
Last updated on Wednesday, March 04, 2020