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Schneider RF, Engelhardt EL, Stobbe CC, Fenning MC, Chapman JD
The synthesis and radiolabeling of novel markers of tissue hypoxia of the iodinated azomycin nucleoside class
Journal of Labelled Compounds & Radiopharmaceuticals (1997) 39:541-557.
Abstract
Seven second-generation hypoxic markers of the iodinated azomycin nucleoside class have been synthesized and tested for hypoxia marking activity with tumor cells in vitro and in vivo. beta-D-lodoazomycin galactoside (IAZG) and beta-D-iodoazomycin xylopyranoside (IAZXP) demonstrated superior hypoxia marking properties relative to IAZA because of their higher water solubilities, rapid plasma clearance rates from tumor-bearing mice and maximum tumor/blood (T/B) and tumor/muscle (T/M) ratios. Our studies with animal tumor models show that T/B or T/M ratios of these markers determined by scintigraphy or planar imaging can predict for the relative degree of tumor hypoxia and for tumor radioresistance.
Note
Publication Date: 1997-07-01.
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