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Roder H, Colon W
Kinetic role of early intermediates in protein folding
Current Opinion in Structural Biology (1997) 7:15-28.
Abstract
The traditional view that partly folded intermediates are important for directing a protein toward the native state has been challenged by the notion that proteins can intrinsically fold rapidly in a single step if kinetic complications due to slow conformational events are avoided. Intermediates that accumulate within the first few milliseconds of folding are, however, a common observation even for small single-domain proteins. Recent spectroscopic studies, coupled with quantitative kinetic analysis, suggest that folding is facilitated by the rapid formation of compact intermediates with some native-like structural features.
Note
Publication Date: 1997-02-01.
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