Lattice_grid_med
Powered by LatticeGrid

Search Enter term and hit return. Use '*' for as a wildcard.
Porter S, Mintz B
Multiple Alternatively Spliced Transcripts of the Mouse Tyrosinase-Encoding Gene
Gene (1991) 97:277-282.
Abstract
We have isolated and characterized tyrosinase-specific cDNAs from wild-type mouse skin, to provide a basis for the structural and functional analysis of mutations at the mouse tyrosinase-encoding (Tyr) locus. The cDNAs were synthesized by the polymerase chain reaction. At least twelve alternatively spliced transcripts of the Tyr gene were found, including nine not previously described. Of 51 clones obtained, most (59%) correspond to the full-length cDNA encoding active tyrosinase. The others are shorter and apparently arose by alternative splicing. They are attributable to exon skipping, usage of alternative 5' and/or 3' splice sites, and (in one case) retention of an intronic sequence. Patterns of alternative splicing also occur in other pigmented tissues.
MeSH terms
Note
Publication Date: 1991-01-15.
Back
Last updated on Wednesday, February 05, 2020